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If tirzepatide stops working for other reasons , that is a different conversation, but heartburn alone is rarely a valid reason for discontinuation
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Attenuation by gastric pentadecapeptide BPC 157, cimetidine, ranitidine, atropine, omeprazole, sulphasalazine and methylprednisolone
The ADA also advises that time above range should not exceed 25% [39]