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In this meta-analysis, compared with trial comparators, GLP-1 analogues had a significant weight advantage in the overweight/obese BMI studies

This is a clinically significant concern, as excessive lean mass loss can negatively impact metabolic health and physical function [42]

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(2), with pGCG = plasma glucagon level, k = slope of the regression line at baseline of SUV 55min (SUV 55min, Baseline ) over plasma glucagon (pGCG Baseline ) Estimation of slope k was based on all n = 13 subjects for whom SUV 55min and plasma glucagon values were available at baseline

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