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If cellular assays are predictive of potential toxicity, the use of animal models allows the evaluation of toxicity signs occurring in response to the gradual increase in the dose of the substance, considering that the biological response could be species-specific and an active ingredient in animals could be completely inactive in humans

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Ibrahim et al., 2024a,b)

The attrition bias and reporting bias were both low as no study was selectively reporting or with incomplete outcome data

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