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The SH2 domain, approximately 100 amino acids in length, specifically recognizes and attaches to phosphorylated tyrosine residues, propagating the insulin signaling cascade

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SLU-PP-332 is a small-molecule pan-ERR agonist that activates an ERR-dependent acute aerobic exercise transcriptional program, increasing energy expenditure and fatty-acid oxidation in vivo without reducing food intake

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