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Spearman correlation analysis showed negative correlations between cytokine levels and a few metabolites, including palmitoylcarnitine, decanoylcarnitine, lauroylcarnitine, and carnosine (Figure 3D)

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Individual pharmacology and genetics: Variability in GLP-1 receptor signaling and metabolic response means some people are simply stronger or weaker responders

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This metabolic acceleration can temporarily elevate oxidative stressthe imbalance between free radicals and antioxidant defensesparticularly during the first 48 weeks of therapy initiation