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10.1007/s004380050456 Mol
doi: 10.1053/j.ajkd.2020.05.015 172
The significance of IDH1 and IDH2 produced NADPH can be made clear by pointing out that cells with low level IDH1 and IDH2 expression are more sensitive to oxidative stress than cells with higher levels of expression of these two enzymes
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However, it seems that glycolysis and not OXPHOS is critical for CSC phenotype since dichloroacetate, a pyruvate dehydrogenase inhibitor, blocks the acquisition of CSC properties [166]
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