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Retatrutide carries one side effect not observed with tirzepatide: dysesthesia, a tingling or burning sensation reported in approximately 20.9% of participants receiving the 12 mg dose in Phase 2 trials [3]

Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)

Bile acid synthesis is the primary mechanism by which excess cholesterol is eliminated from the body (Shah, 2003)

Identifying these mutations may guide preventive measures and treatment