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doi: 10.3389/fphys.2022.954948 Received 27 May 2022 Accepted 28 July 2022 Published 25 August 2022 Volume 13 - 2022 Edited by Robert Roghair, The University of Iowa, United States Reviewed by Jeffrey Segar, Medical College of Wisconsin, United States Michael Satterfield, Texas A&M University, United States Updates Copyright 2022 Stremming, White, Donthi, Batt, Hetrick, Chang, Wesolowski, Seefeldt, McCurdy, Rozance and Brown

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Early assessments revealed limited adherence to procedural pain guidelines and inconsistent sedation practices, and more recent studies confirm persistent gaps in pain assessment, analgesic administration and appropriate sedative use during invasive procedures ( Necrotizing enterocolitis (NEC) highlights the complexity of neonatal pain and sedation