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Figure 1 4 Evidence framework and phenotypic heterogeneity of GLP-1RA-associated taste-related changes In real-world obesity treatment, some patients receiving GLP-1RAs report changes in eating experience, such as food tastes different, food is no longer appealing, or the emergence of unpleasant taste sensations (66) to broader concepts such as food taste change or patient-reported alterations in flavour evaluation (67)
They also had lower triglycerides, lower low-density lipoprotein cholesterol, higher high-density lipoprotein cholesterol, and lower HbA1c levels
Reasons for these changes include: Shifts in hunger hormones Changes in gutbrain signaling Altered sleep patterns A faster or slower adjustment of the nervous system to new eating habits Most mood changes improve as the body adjusts to the medication
The GLP-1 peptide is a naturally occurring hormone produced by the gut that sends signals to the brain affecting metabolism and appetite
