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Molecular mechanisms of necroptosis: An ordered cellular explosion

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While immunodeficient zebrafish models permit the engraftment of human immune cells, they possess an intrinsic limitation for studying immune-driven inflammatory processes that require functional adaptive immunity

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Circulating Fe 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)