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The STEP clinical trial program provided pivotal evidence, showing that patients receiving semaglutide 1.0 mg weekly lost an average of 15% of their body weight over 68 weeks, with 86% achieving at least 5% weight loss compared to just 31% in the placebo group

Mol Biol Cell 17: 10181032

Body Composition Changes Research published in Diabetes, Obesity & Metabolism in 2024 specifically addressed body composition during GLP-1 treatment, noting that supportive nutrition including adequate minerals may help optimize outcomes (PMID: 39344838)

It is almost impossible to conduct a prospective study that requires a large number of patients with CP and long-term follow-up

It clears the bloodstream in under thirty minutes, yet users claim effects lasting days

Glucose regulation Some of that control is likely due to semaglutides ability to regulate blood glucose