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In regards to the insulin signaling pathway, high concentrations of H 2 O 2 /O inhibit insulin receptor substrates and the PI3K/AKT pathway through oxidative stress, leading to the development of insulin resistance [179, 180]

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Introduction Thymosin beta-4 (T4) is a 4.9-kDa actin-sequestering peptide that contains 43 amino acids [1]

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