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Oxidative stress activates microglia and reactive astrocytes, inducing inflammation, leading to cellular damage

In particular, [1- 13 C]DHA, a 13 C enriched version of dehydroascorbic acid, has been studied with hyperpolarized (HP) 13 C magnetic resonance (MR) in preclinical models of cancer, diabetes, acute kidney injury, and fatty liver disease 15,16,17,18,19,20

With no human trials and no FDA approval, it remains strictly experimental

Garnis, C., et al

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Moreover, cancer cells upregulate antioxidant pathways to maintain redox balance amidst oxidative stress and mitochondrial dysfunction, crucial for their survival (139141)