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Avoid overcooking

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A 1mg intranasal dose could theoretically match or exceed the brain exposure of a 3mg oral dose, though nasal administration introduces variability based on mucosal absorption and nasal cavity drainage

Weekly Schedule Example Option A (standard): 1 mL once weekly 10 doses (10 weeks) Option B (enhanced): 1 mL twice weekly 10 doses (5 weeks) Option C (light): 0.5 mL once weekly 20 doses (20 weeks) 4

Critically, never shake the vial after adding water