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In addition, IGF-IR inhibition sensitizes cancer cells to other chemotherapeutic agents, such as paclitaxel, 5-fluorouracil (5FU), temozolomide, gemcitabine, and bortezomib [101,102,103,104,105]

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Jaganjac M, Borovic Sunjic S, Zarkovic N

Dsip can be metabolized and excreted in the liver, kidneys, and other tissues

System Xc: A key regulatory target of ferroptosis in cancer

The down-regulation of HIF-1 significantly reduces synovitis and angiogenesis, which may be a potential therapeutic target for RA (213)