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In recent GLP-1RA trials focusing on patients with obesity, favourable effect on worsening heart failure in HFpEF patients was indicated to be modulated by baseline BMI [32], although the underlying mechanisms that explain the cardiovascular and renal benefits may not necessarily be due to weight loss alone

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patients with a personal or family history of medullary thyroid cancer should avoid GLP-1 agonists

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Nucleosides Nucleotides Nucleic Acids 30 , 10181029 (2011)

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