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Pharmaceutical inhibitors like finasteride block both types systemically, which explains their effectiveness but also their side effect profile
For researchers investigating metabolism, aging, neurodegeneration, and age-related diseases, NAD+ represents a convergence point where fundamental biochemistry meets translational medicine, offering insights into basic biological processes while pointing toward practical interventions that could significantly impact human health and longevity
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However, elevated levels of GSH in tumor cells are able to protect such cells in bone marrow, breast, colon, larynx, and lung cancers by conferring resistance to several chemotherapeutic drugs (Wu et al., 2004
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