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2B) was 0.77 at 3 months, 0.65 at 6 months, 0.38 at 9 months, and 0.27 at 12 months in not treated subjects

The apo-peptide (GHK without copper) shows significantly reduced activity in most research models

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de Magalhes, 2025).Additionally, the combination of senolytics with autophagy enhancers or anti-inflammatory agents has shown synergistic effects on OA symptom relief and structural repair (Garcia-Dominguez et al., 2025).Parallel advances have emerged in ferroptosis research, revealing that this iron-dependent oxidative cell death plays a key role in chondrocyte dysfunction in OA

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The limited number, small sample sizes of studies, and methodological diversities may weaken the statistical power