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In this regard, a human study found that subjects who took tesofensine for 24 weeks and then stopped taking it for 12 weeks did not regain all their lost weight [19]

By acting as a selective 2-adrenergic agonist at the locus coeruleus and dorsal horn, DEX provides calm, physiological sedation while decreasing pain signal transmission without affecting breathing (Figure 2) (82, 229)

Paediatr Anaesth 2005;15:167-70

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Journal of Biological Chemistry 279:4952349532

typically improve with gradual dose titration and lifestyle support