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Obesity is particularly significant, as excess adipose tissue increases lymphatic load and may directly impair lymphatic vessel function through inflammatory mechanisms

88 In knockout mouse melanoma cells, nilotinib was found to upregulate MITF (melanocyteinducing transcription factor) and its downstream genes via activation of the cAMP/PKA/CREB pathway and decreased phosphorylation of AKT

Its inclusion is not an endorsement