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Celastrol-loaded enzyme-responsive nanoparticles dually target osteoclasts and inflammatory macrophages derived from patients with RA, leading to increased apoptosis of these cells

At 5 mg/mL, even moderate doses result in very small volumes (300 mcg = 0.06 mL, ~6 units)

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Combined NNMT inhibitor treatment with reduced-calorie diet achieved 6.3 g cumulative weight loss versus 2.9 g with diet alone, and fat mass reduction was ten-fold greater with treatment (~29.3%) compared to diet switch alone (2.9%), while restoring fatty liver profiles to lean-control levels (Sampson et al., 2021)