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SURPASS-4 was an open-label global trial comparing the safety and efficacy of tirzepatide with titrated insulin glargine in 2002 people with T2DMwith an increased CV risk who were treated with metformin, a sulfonylurea, or an SGLT-2 inhibitor

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12.3 Pharmacokinetics Semaglutide estimated mean steady-state concentration was 6.7 nmol/L and 14.6 nmol/L following once daily oral administration of 7 mg and 14 mg of RYBELSUS (formulation R1), respectively, in patients with type 2 diabetes mellitus

After washing with cold PBS, the cellular uptake of NP4 was measured via CLSM

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