While it is unlikely that GLP-1 and/or GIP contribute to the pathology of type 2 diabetes mellitus, pharmacotherapeutics targeting both GIP receptors and GLP-1Rs in individuals with type 2 diabetes may offer further benefits than GLP-1R agonism alone [34]
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Science 289 , 15041508 (2000)
Over the past few years, incretins have been clinically validated as targets and are now the emerging standard of care therapies in obesity, but could also be effective in other metabolic indications, as well as in cardiovascular and chronic kidney disease
Each is a single-piece, low-resistance, gold-plated adapter
(Article in Japanese) Takahashi A