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In the present study, we established a rat model of -cell failure using LOsG and found that high glucose promoted PSC activation and proliferation to enhance pancreatic fibrosis

This study was supported by National Key R&D Program of China (2023YFC2509100), Science and Technology Commission of Shanghai Municipality (23Y31900400), National Natural Science Foundation of China (82370984 & 82370980), Natural Science Foundation of Shanghai (22ZR1437600), Shanghai's Top Priority Research Center (2022ZZ01017), and Dominant disease biological sample project of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (YBKA202201)

The trRosetta results produced five top models for each entry, of which the one with the greatest estimated TM-score (e-TM) represented the best model and was selected for this study

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