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Page MJ, McKenzie JE, Bossuyt PM et al (2020) statement: an updated guideline for reporting systematic reviews

Those with sluggish detoxification pathways

We are really only concerned about toxicity from fat-soluble vitamins (A, D, E, and K)

For those who don't care for a shot, oral supplementation with the two active forms of B12, methylcobalamin and adenosylcobalamin, may be as effective as a B12 shot