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What they found: Plasma NAD+ increased by 60 % in the NR arm Mild reduction of systolic blood pressure by 6 mmHg Improvement in arterial stiffness (markers of endothelial function) No effect on glycemia in the healthy population Excellent safety profile , no serious adverse events Why it matters: The study validated the oral bioavailability of NR and the ability to long-term increase the NAD+ pool in humans

doi: 10.1002/jcp.21172

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