They occur during REM sleep, when the brain is more apt to vivid dreaming, and consist of very realistic and disturbing events
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The trade-off is higher cost and the requirement for clinical administration
Another hypothesis is that the circadian rhythm in the pituitary may synchronize the unitary ultradian activities of GH-secreting cells through a long-distance homotypic cell network ( In addition, studies have confirmed that the disruption of the circadian clock system affects the release of GH and GH-mediated signal pathways
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