glp-1 aspiration the biggest danger of include the stomach not emptying which can lead to during surgery or even when sleeping, #GLP #surgery #weightloss #infertility #IVF #ttc #infertilitywarrior Aspiration risk tops anesthesiologists' concerns

In December 2025, Eli Lilly announced positive topline results from TRIUMPH-4 a 68-week Phase 3 trial in adults with obesity and knee osteoarthritis in which retatrutide delivered average weight loss of up to 71.2 lbs alongside substantial reductions in osteoarthritis pain

Note: Some GLP-1s are not approved for weight loss, but some doctors may prescribe them off-label for this use

The conversion guidance that exists for transitioning between other GLP-1 agonists can provide some framework for thinking about dosing during transitions, though no specific tirzepatide-to-retatrutide conversion protocol has been established in clinical literature

Currently, the Wegovy pen (injection) list price is $1,349 per month, though the company recently announced that it will reduce the price to $675 per month, starting in 2027

Mizumoto J

You may notice reduced appetite suppression during the gap, but blood levels will rebuild quickly once you resume