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The decreased NO activity and further deactivation by superoxide anion radical increase vascular resistance in renal arteries and manifest as hypertensive nephropathy and CVD [27].CKD patients have severe vitamin D deficiency that is further decreased by reduced activity of the enzyme 1- hydroxylase (CYP27B1), which converts 25-hydroxyvitamin D to its more active form, 1,25-dihydroxyvitamin D

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Serrano, L.M., Molenaar, D., Wels, M., Teusink, B., Bron, P.A., De Vos, W.M., et al., Microb

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Biomarker and genetic context can inform these conversations, but medical assessment and symptom tracking remain the foundation of safe, personalized treatment adjustments

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