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It avoids androgenic side effects common with anabolic steroids

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The kidneys cellular heterogeneity and complex architecture pose challenges for directly assessing the pharmacologic effects on kidney oxygenation and hypoxia-responsive pathways in vivo, such as treatment with SGLT2 inhibitors (SGLT2i), presumed to impact kidney oxygenation

Store in a cool, dry place, away from direct sunlight and out of reach of children

The torsion domain, upon ATP hydrolysis, leads to directional DNA translocation, destroying histone-DNA contacts and creating a transient DNA loop