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This induction is significantly attenuated in Nrf2-deficient keratinocytes, indicating that 4-HNEs effects are mediated, at least in part, through the Nrf2 pathway [45]

Because glutamine metabolism is involved in NADPH production and GSH formation, glutamine pathway inhibitors could be useful anti-cancer partners

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Specifically, the occurrence of ANA may suggest an autoimmune-mediated liver injury in Wilson disease, best termed CIAIH, analogous to drug-induced autoimmune hepatitis (DIAIH)