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Winzeler B, da Conceio I, Refardt J, Sailer CO, Dutilh G, Christ-Crain M (2019) Effects of glucagon-like peptide-1 receptor agonists on hypothalamic-pituitary-adrenal axis in healthy volunteers

The mechanism is fascinating and highly specific to lupus pathology

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GLP-1 receptor agonists work by mimicking the action of endogenous GLP-1, a hormone that stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

In 24 weeks: Participants lost an average of 5% of their starting weight on the highest dose

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