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Both approaches work, as long as storage protocols are followed

Thus, inhibition of DPP-IV has been suggested as a feasible alternative to elevate circulating GLP-1 levels, and circumvent the limitations of GLP-1 administration [323][324][325][326][327][328][329][330]

Similarly, GLP-1 binds to GLP-1-receptors (GLP-1r) and causes the same glycemic effect as GIP on the pancreas

The fundamental difference between these two compounds lies in their receptor targeting strategies

In the pancreas, semaglutide enhances glucose-dependent insulin secretion, meaning it only triggers insulin release when blood sugar is elevated

Regarding FDA approvals , Mounjaro is primarily approved for managing type 2 diabetes , although it has shown significant weight loss in studies