4.2 Dysbiotic microbiome stimulates cyclooxygenase-2 expression, affects gastric emptying, and induces GERD Cyclooxygenase-2 (COX-2) is the rate-limiting enzyme that catalyzes the initiating step in the metabolism of arachidonic acid to prostaglandin H2 and is a precursor to prostaglandins such as prostaglandins, thromboxanes, and prostacyclins, which act as autocrine and paracrine lipid mediators in the maintenance of local homeostasis by mediating vascular function, wound healing, and inflammation (52)
Why could these effects be concerning for eating disorder treatment
3 Not all medications are available for home delivery
For individuals taking Ozempic, maintaining adequate nutrition becomes particularly important as the body undergoes metabolic changes and, in many cases, significant weight loss
Frequent heavy drinking undercuts sleep, recovery, and metabolism broadly, which are the systems most peptide protocols are built around
Lancet 398 , 6477 (2021)