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By months four through six, the medication has generally reached its target dose and patients are experiencing its full metabolic effect

Propionyl-CoA Carboxylase Propionyl-CoA carboxylase converts the propionyl-CoA derived from the oxidation of valine, methionine, isoleucine, and threonine, as well as fatty acids with odd numbers of carbon acids, into methylmalonyl-CoA

These associations remained significant after adjustment for maternal age, body mass index (BMI), parity, and gestational age at sampling (Table 4)

Additionally, uricase can cause gastrointestinal discomfort, including nausea and vomiting, leukopenia, hair loss, and other adverse reactions

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