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Severe allergic reactions requiring medical intervention have been exceptionally rare in published studies, with no documented cases of life-threatening anaphylaxis in the Phase 2 trials

Bessette and Anderson found that 89% ( 95% CI, 87.9-90.1), 88.9% (95% CI, 87.8-90) and 90.6% (95% CI, 89.5-91.6) of the cohort met the criteria for treatment with semaglutide, liraglutide (Saxenda, Novo Nordisk) and tirzepatide (Zepbound, Eli Lilly), respectively

Both compounds have half-lives suitable for once-weekly dosing: Tirzepatide: ~5-day half-life Retatrutide: ~6-day half-life (estimated from Phase 2 pharmacokinetic data) Best Peptides for Fat Loss: Where Do These Compounds Rank

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PMID: 41931049