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19, 20 The latter observation led to a recently completed phase I trial of BSO+L-PAM given with stem cell support in the New Approaches to Neuroblastoma Therapy (NANT) consortium that has safely dose-escalated L-PAM given with BSO to myeloablative L-PAM doses, with the stem cell infusions overcoming the expected hematopoietic toxicity (www.NANT.org

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To the best of our knowledge, human pharmacokinetic studies investigating these aspects in detail in a procyanidin-rich pine bark extract, have been only performed for Pycnogenol