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We estimated the percent mediation of the change in eGFR at week 104, potentially attributable to change in weight, by assessing how much the treatment effect on eGFR was altered by including the weight change in the regression model adjusted for baseline eGFR and baseline weight

Patients report reduced cravings, smaller portion sizes, and a general disinterest in food they previously found compelling

Humanin also modulates the activities of caspases, key mediators of cell death pathways, thereby promoting cell survival in stressful conditions (Nakagawa et al., 2002)