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While rare overall, risks amplify with: History of pancreatitis/gallstones : Contraindicated or high caution

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When aspiration pneumonia is suspected, guidelines suggest beta-lactam/-lactamase inhibitor regimens (e.g., ampicillin-sulbactam), reserving clindamycin for patients with -lactam allergy or for classic anaerobic infection syndromes such as lung abscess, necrotizing pneumonia, or empyema (Simpson et al