In the context where immune checkpoint blockade (ICB) has demonstrated remarkable efficacy in cancer immunotherapy, several studies have revealed the reduced effectiveness of anti-PD-1/PD-L1 therapy in aged mice and elderly patients, 207,208,209 leading to treatment resistance
Specifically, damage to the pancreatic acini and islets of Langerhans was observed, accompanied by an increase in collagen deposition in the pancreatic parenchyma, a decrease in serum insulin levels, and an increase in blood glucose levels
doi: 10.1371/journal.ppat.1007581 83 DinkovB
When this happens, your body struggles to keep up, leading to: Increased oxidative damage
For patients with metastatic disease, determining the stage is crucial for identifying those who are likely to benefit from certain next-gen treatments
Part D enrollees using a GLP-1 for type 2 diabetes, sleep apnea, or other Medicare-covered uses will continue accessing the drug through their Part D plan and paying their plans cost-sharing requirement, even if its more than the $50 copayment for GLP-1s for obesity under the Medicare GLP-1 Bridge
