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Overcoming the drug resistance of MET-TKIs and ICIs, as well as their toxic and side effects that may affect the drug efficacy, remains a critical challenge

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For weight management specifically, NICE technology appraisal (TA875) recommends Wegovy within a specialist weight management service for adults with at least one weight-related comorbidity and either a BMI of at least 35 kg/m (or 32.5 kg/m in people from minority ethnic groups) or a BMI of at least 30 kg/m (27.5 kg/m in people from minority ethnic groups) and previous specialist weight management services

Brucein D augments the chemosensitivity of gemcitabine in pancreatic cancer via inhibiting the Nrf2 pathway

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