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GLP-1 drugs appear to have direct protective effects on the cardiovascular system, reducing inflammation, improving endothelial function, and potentially stabilizing atherosclerotic plaques

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The effects of therapeutic and supra-therapeutic doses of CGV on serum biochemical indices in male rats were assessed (Table 3)

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Sep 13 2021;doi:10.22037/uj.v18i.6325

These findings indicate that GLP-1R activation specifically inhibits GSDMD-mediated microglial pyroptosis, a finding consistently replicated in subsequent in vitro experiments (Song et al., 2022)