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The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-Met system

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21 , 22 , 23 In our experiment, BLM upregulated the expression of TGF1 mRNA level, and FOXO4DRI downregulated TGF1 expression in BLM treatment mouse (Figure 1E)

[9] Depending on this modified state, FOXO4 binding affinity for DNA is altered, allowing for FOXO4 to regulate many cellular pathways including oxidative stress signaling, longevity, insulin signaling, cell cycle progression, and apoptosis

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