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Your body can potentially use stored fat for energy while simultaneously using dietary protein and amino acids for muscle protein synthesis

Liu, Y., Hazlewood, G

Significant fat loss usually begins once you reach a stabilised, higher therapeutic maintenance dose

A multidisciplinary advisory from major nutrition, lifestyle medicine, obesity medicine, and obesity research organizations recommends screening dietary intake, medical conditions, strength, function, physical activity, and other lifestyle factors when initiating GLP-1 therapy

That combination is why early retatrutide data looked almost implausibly good

What emerges is a coherent biological framework: estrogen maintains the mitochondrial infrastructure and synaptic stability that neurons depend on for sustained function, while GLP-1 receptor activation reduces the inflammatory burden that progressively degrades that infrastructure