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In addition, it was shown that the factors of diabetes duration, sex percentage, study sample size, studies with significant results, and comparisons between GLP-1RAs and placebo could clarify the sources of the heterogeneity

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Unlike native IGF-1 which has a short half-life of only 2030 minutes IGF-1 LR3 has been modified by replacing the third amino acid with arginine and extending the peptide chain by 13 additional amino acids

10.3389/fnins.2024.1463038 Front