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Biochemical evidence for the dynamic features of the complex Our cryo-EM analysis supported several conclusions: (i) SL hydrolysis by HTL7 destabilises its lid domain, which is a prerequisite for binding to MAX2, (ii) SMAX1 binds to the complex with at least two domains (N and D2) in a flexible and dynamic manner, and (iii) D2 binding stabilises the association of HTL7 with MAX2
ABOUT THIS EPISODE English United States TRANSCRIPT Are you the producer of this podcast
Lien, T
Jensterle M, Kocjan T, Kravos NA, Pfeifer M, Janez A
Most patients see renewed weight loss within 2-3 weeks of starting Zepbound, even at the 2.5 mg starting dose
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