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doi: 10.3389/fphar.2022.1026182 Received 23 August 2022 Accepted 23 November 2022 Published 14 December 2022 Volume 13 - 2022 Edited by Junmin Zhang, Lanzhou University, China Reviewed by Yurong Lai, Gilead, United States Mei-Hua Qu, Weifang Second Peoples Hospital, China Updates Copyright 2022 He, Feng, Guo, Zhou, Li, Zhang, Zhang, Wang, Wang, Hao, Zhang, Gao, Gu, Zhang, Li and Li

Diet Your diet is the single biggest contributing factor

Fong's Pro Tip: Elevate your legs for 15 minutes a day to improve blood flow and reduce fluid retention

These include stress management, adequate sleep (as sleep deprivation worsens insulin resistance), and smoking cessation

Should be used with caution in individuals with peripheral vascular disease, as it may worsen symptoms

Bivona G, Agnello L, Ciaccio M