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A review by McCann et al
No equilibration step was included before measurements
This is because a small amount (about 1%) is absorbed passively via diffusion
As weve mentioned, CR decreases NADH (in yeast), which increases (i.e, improves) the NAD + : NADH ratio
aeruginosa , the MexR repressor senses oxidative stress (two Cys residues form disulfides), dissociates from the mexAB-oprM promoter, and derepresses efflux under peroxide stress
This antioxidant activity is vital because excessive ROS can impair mitochondrial function, leading to oxidative stress and affecting the energy production of neurons and glial cells, potentially causing migraine headaches ( Vitamin B2 deficiency disrupts intermediary metabolism, potentially impairing energy production via the ETC, which is mainly concerned for the nervous system, given its high energy demands, and also can lead to disorders, such as migraine, because of energy failure, alongside overproduction of ROS (47)
