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3.5 Metformin significantly increases total glutathione production in CRC cells in vitro As the majority of DNA damage induced by radiation is via indirect action, in particular oxidative damage, and given the demonstrated metformin-induced ROS production in HCT116 and SW837 cells ( Figure 1D ), the impact of metformin treatment on anti-oxidant capacity was assessed

HRES-1/Rab4 promotes the formation of LC3 + autophagosomes and the accumulation of mitochondria during autophagy

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10.1016/j.exger.2010.01.003 [DOI] [PMC free article] [PubMed] [Google Scholar] *.Chandel NS