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Targeting of ECM molecules and their metabolizing enzymes and receptors for the treatment of CNS diseases

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( b ) Mean changes in cADDis fluorescence of sustained (n = 117 cells), transient (n = 66 cells), and forskolin (Fsk) only (n = 373 cells) responders from AP slices (n = 6 slices, 3 mice, 2 males) in response to bath application of semaglutide (100 nM) followed by forskolin (10 M)

Most of these upregulated pathways were downregulated by TS, including arginine biosynthesis, aminoacyl-tRNA biosynthesis, GABAergic synapse, D-amino acid metabolism, central carbon metabolism in cancer, and protein digestion and absorption, among others (Figure 3D)

26 Main characteristics of these RCTs are summarized in Table 1

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